![]() Genetic studies indicate that geographical and climatic contexts affect a high diversity of H. Therefore, it can be used as a reliable biological marker for the simultaneous evolution of host–pathogen and ancient human migration based on the diversity of sequences at the selected gene site. Given that the microorganism has been probably in the human stomach for millions of years, it is considered to have evolved with its host. pylori is a panmictic species in which no diagnosable strong clonal structure exists. This feature allows the exchange of genetic matter between different strains living together in a stomach. pylori is naturally competent and can integrate a foreign DNA with homologous recombination into its genome. Extensive allelic diversity, genetic variability, mutations, and high recombination are prominent features of this microorganism. Infections caused by this bacterium are usually acquired in childhood and can remain asymptomatic for several years. pylori) is a Gram-negative spiral bacillus isolated from patients with chronic gastritis (CG) by Marshall and Warren in 1984. Genetic diversity of Helicobacter pylori isolates from patients with gastric diseases in Isfahan. How to cite this URL: Vazirzadeh J, Karbasizadeh V, Falahi J, Moghim S, Narimani T, Rafiei R. How to cite this article: Vazirzadeh J, Karbasizadeh V, Falahi J, Moghim S, Narimani T, Rafiei R. Keywords: Helicobacter pylori, multilocus sequence typing, prevalence Sequence analysis and determination of the origin of the phylogeny of strains can be effective in clinical management and monitoring of risk factors for chronic and recurrence of infection. pylori infection in this region, early and accurate identification of patients seems necessary. Conclusion: Given the high prevalence of H. The results of the global analysis showed that all the isolates, with a wide diversity, have a genetic affinity with members of the European population, such as Italy and Russia, and are in the hpEurope haplotype. In the results of the analysis of MLST, a total of 14 new STs were recorded. The phylogenetic tree was plotted using CLC v8 and iTol software. MLST of seven housekeeping genes was performed for 20 H. pylori infection was determined by FISH in paraffin-embedded biopsy specimens. Shariati Hospital of Isfahan, Iran, from April to July 2018. Materials and Methods: In this descriptive cross-sectional study, 165 gastric biopsy specimens were obtained from patients with dyspepsia referred to Dr. pylori isolates from patients with dyspepsia by the multi-locus sequence typing (MLST) and update data on the prevalence of H. This study aimed to determine the genetic diversity of H. This pathogen is highly diverse and can be used as genetic markers for predict the history of human migrations. pylori), a spiral-shaped bacterium colonizing the human stomach, is generally acquired in childhood. ![]() Fixed an issue where the "Empty Recycle Bin" option was sometimes incorrectly unavailable.Background: Helicobacter pylori (H.Fixed an issue that led to an error when rendering plots for empty data sets.Side panel option to show legends for a plot with more than 10 samples is now enabled.Fixed saving different line colors in plots through the side panel.Plots inside reports are now shown with their saved side panel settings.Fix of potential wrong file being saved when editing a file found via the Local Search Editor.Fixed wrong display of "Supported format" when exporting elements from either the Folder Editor or the Local Search Editor.When installing a workflow with bundled data, it is no longer possible to select a read-only folder for storing the data.All reverse translation would thus default to the standard genetic code. The Reverse Translate tool ignored any genetic code specified in the codon frequency tables.A fix was applied to avoid an exception in circumstances when the cleanup of downloaded files from BLAST failed. ![]()
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